Pramipexole in Treatment Resistant Depression: A Case Review
نویسندگان
چکیده
Pramipexole is a dopamine agonist used in the treatment of Parkinson’s disease and Restless legs syndrome. Although off-label, use as an adjunct therapy resistant depression has recently been documented literature with promising results. We present 75-year-old male MDD who failed trials SSRIs, SNRIs, TCAs, SGA, TMS, Ketamine, ECT was initiated on Pramipexole. discuss, based existing literature, probability favorable long-term response to potential side effects for our patient. also highlight need future studies designed test efficacy geriatric patients TRD.
منابع مشابه
Dextroamphetamine and Pramipexole Combination for Treatment-Resistant Unipolar Depression.
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Despite a wide range of various drugs, a significant proportion of depressed bipolar patients fail to respond to the treatment strategies. Novel theraupetics for bipolar depression are needed. Preliminary studies suggest that pramipexole a dopaminergic agent that has been used in the treatment of Parkinson's disease and restless leg syndrome may have antidepressant properties in unipolar and bi...
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Depression is a common symptom and a major public health problem in the elderly. Despite its prevalence and seriousness, depressive disorder in older people remains under-treated. The optimal treatment of depression in later life is crucial, and requires appreciation of several age-related factors such as comorbidity, polypharmacy, altered drug kinetics, variable treatment response and increase...
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Dopaminergic dysfunction is implicated in the pathophysiology of treatment-resistant depression. Although the efficacy of adjunctive pramipexole treatment has been demonstrated in treatment-resistant bipolar depression, such data are scarce for major depressive disorder (MDD). We recruited 17 patients with DSM-IV major depressive episode who have failed to respond to previous treatment with a s...
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Major depressive disorder in youth is associated with significant mortality by suicide [1], protracted course of illness [2], high risk of recurrence [3], significant nonresponse to treatment [4,5], progression to bipolar disorder within 5 years [6-8], and high frequency of affective illness in family members [9]. Even with the gold standard treatment with an SSRI and concurrent cognitive behav...
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ژورنال
عنوان ژورنال: Pharmacology & Pharmacy
سال: 2023
ISSN: ['2157-9423', '2157-9431']
DOI: https://doi.org/10.4236/pp.2023.147016